Rat PVN — immobilization stress (bulk RNA-seq)
Rattus norvegicus · Paraventricular nucleus · bulk RNA-seq
Selected data and study scope
This dataset contains bulk RNA-seq data from Rattus norvegicus, sampled from paraventricular nucleus. The default comparison examines gene expression in Immobilization stress relative to Untreated control.
The explorer includes 1 track and 1 comparison for this dataset.
The default track, Paraventricular nucleus (PVN), includes 5 Untreated control samples and 5 Immobilization stress samples in this comparison. These are analysis sample counts. Check the source for biological replication and pooling.
Interpretation and limitations
The measurement combines expression from the cells in the tissue sample. A difference in tissue expression alone does not identify which cell type contributes to it.
Expression values use log2(FPKM + 1). Keep this unit when exporting or comparing values. Values on other normalization scales are not directly interchangeable.
Evidence and verification
Pipeline QC passed. Rat PVN — immobilization stress (bulk RNA-seq); all 1 registered contrasts on default track pvn
Experimental design passed. Rat PVN — immobilization stress (bulk RNA-seq); all 1 registered contrasts on default track pvn
Author concordance not assessed. Author effect concordance has not been assessed
Pipeline QC can pass while experimental-design limitations remain. Read both assessments before interpreting results.
Open the dataset in the Explorer to read each check and its evidence. Author concordance compares effects for matched genes. It does not require identical author P values or FDR.
Read the analysis methods and interpretation guide and how to cite the source study and HypoExplorer. The source publication may include tissues, groups or comparisons beyond the data shown here.
Source study
Male Sprague-Dawley-rat PVN after no treatment vs six hours/day immobilization for one week, n=5/5 independent animals. The minocycline rescue arm is excluded (PMID 39935443; GSE261833)
Source publication
Lin PQ, Pei QW, Li B, Yang JM, Zou LN, Su DZ, et al.
Journal of geriatric cardiology : JGC · 2024
Repository study title
Role of hypothalamic microglial activation on ventricular arrhythmias in stress cardiomyopathy
The original study authors produced these data. HypoExplorer displays selected data and analyses that may cover only part of the study.
Comparisons in HypoExplorer
Immobilization stress vs Untreated control · default
Positive differential-expression values indicate higher expression in the case group relative to the baseline. Check the comparison direction and study design when interpreting results.
Available tracks
| Track | Features | Untreated control n | Immobilization stress n |
|---|---|---|---|
| Paraventricular nucleus (PVN) | 16,117 | 5 | 5 |
Expression and analysis results
Open this dataset to inspect gene expression and differential-expression results across the available tracks. Pathway enrichment is also available. The pathway databases differ by dataset.
HypoExplorer is in beta testing. Features and analyses may change during testing. Review the original source, analysis methods and quality-control checks before using a result in research.