Hypothalamus datasets and source studies

Macaque hypothalamus (snRNA-seq)

Macaca fascicularis · snRNA-seq · Whole hypothalamus

Obese vs Normal

Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus.

PMID 38325338

Mouse whole hypothalamus (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

HFD vs Chow

GPR101 loss promotes insulin resistance and diet-induced obesity risk.

PMID 40655975

Mouse arcuate nucleus (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Arcuate nucleus

HFD vs Chow

Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice.

PMID 38145289

Mouse arcuate nucleus — HFD (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Arcuate nucleus

HFD vs NCD

The sperm quality in DIO male mice is linked to the NF-κB signaling and Ppp2ca expression in the hypothalamus.

PMID 40160428

Mouse hypothalamus — NZO HFHS (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

HFHS vs Control diet

Genotype-by-diet interactions in diabetes susceptibility, NZO/HlLtJ hypothalamus (GSE235479)

Mouse whole hypothalamus — HFD vs LFD (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

HFD vs LFD

Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N.

PMID 30353127

Mouse hypothalamus — pooled 14/17-day overfeeding effect (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Overfeeding vs Control

Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.

PMID 38331907

Mouse hypothalamus — HFD time-course (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

HFD 12w vs HFD 0d

HFD day-0 baseline vs 12 weeks, whole hypothalamus (longitudinal trajectory; no chow arm) (GSE305719)

Mouse hypothalamus — chow vs HFD (brain atlas; bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

HFD vs Chow

An RNA-seq atlas of mouse brain areas during fasting and diet-induced obesity.

PMID 38184639

Mouse hypothalamic astrocytes — chow vs HFD (TRAP-seq)

Mus musculus · TRAP-seq (translatome) · Whole hypothalamus

Sham-HFD vs Sham-Chow

Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice.

PMID 37053049

Mouse paraventricular nucleus — chow vs HFD (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Paraventricular nucleus

HFD vs Chow

Minocycline Reduces Hypothalamic Microglia Activation and Improves Metabolic Dysfunction in High Fat Diet-Induced Obese Mice.

PMID 35784876

Mouse hypothalamus — control vs HFD obesity (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Obesity vs Control

A Predictive Transcriptomic Approach to the Resveratrol-Mediated Reversal of Hypothalamic Alterations in a Mouse Model of Obesity.

PMID 41898832

Mouse hypothalamic astrocytes — chow vs HFHS (bulk RNA-seq)

Mus musculus · bulk RNA-seq (sorted astrocytes) · Whole hypothalamus

HFHS vs Chow

Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner.

PMID 35802021

Mouse lateral hypothalamus — high-fat diet (scRNA-seq)

Mus musculus · scRNA-seq · Lateral hypothalamus

High-fat diet vs Control chow

Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding.

PMID 31249056

Rat arcuate nucleus — high-fat diet (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Arcuate nucleus

High-fat diet, sedentary vs Chow, sedentary

Exercise Rescues Obesogenic-Related Genes in the Female Hypothalamic Arcuate Nucleus: A Potential Role of miR-211 Modulation.

PMID 39000297

Mouse hypothalamic neurons — palmitate stress (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Palmitate (5 mM) vs Vehicle (BSA)

Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons.

PMID 39916981

Rat hypothalamus — peri-adolescent high-fructose diet (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

High-fructose diet (55%) vs Standard chow (0.30% fructose)

High-fructose diet during periadolescent development increases depressive-like behavior and remodels the hypothalamic transcriptome in male rats.

PMID 26356038

Rat hypothalamus — high-fat diet (WTTS-seq)

Rattus norvegicus · WTTS-seq (3′ termini) · Whole hypothalamus

High-fat diet / DIO vs Standard chow

Mapping diet-induced alternative polyadenylation of hypothalamic transcripts in the obese rat.

PMID 29391168

Rat ventromedial hypothalamus — high-fat diet (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Ventromedial hypothalamus

High-fat diet vs Low-fat diet

Identification of novel candidate neural genes for diet-induced obesity in outbred heterogeneous stock rats.

Mouse arcuate diet and glucose response

Mus musculus · snRNA-seq · Arcuate nucleus

HFD vs chow with saline; HFD vs chow with glucose; Glucose vs saline on chow; Glucose vs saline on HFD

ARC/VMH cells aggregated by hashed mouse after submitted discard/doublet filtering. DVC cells are excluded using cell anatomy and Arc animal IDs. Major classes require 20 nuclei per mouse; Ghrh requires 10. Each displayed population retains at least three mice in all four arms. The pilot GSE262408 is a separate cohort and is not included.

Mouse ventral hypothalamus - chronic high-fat diet

Mus musculus · bulk RNA-seq · Ventral hypothalamus

Chronic HFD vs regular chow

Chronic 45%-fat HFD versus regular chow in male C57BL/6J ventral/circumventricular hypothalamus. Five RNA pools per arm, each pooled from two mice; individual pool members are not deposited. Diet-switch arms are excluded. Technical sequencing runs were merged by the authors and are not replicates. The author supplied PORT-normalized resampled read counts, not raw counts. Same-symbol rows are summed on the deposited linear scale and transformed as log2(PORT-normalized read count + 1) for the matrix/limma route. All mice underwent three hours of forced wakefulness before ZT6-7 collection with food available. The chronic contrast includes diet and resulting obesity, and does not isolate diet from body weight. The downloaded file contains 21,654 Ensembl rows and 21,518 unique trimmed author symbols, whereas the paper reports 21,517 detected genes; the authentic file is retained without forcing its dimensions to match the paper.

PMID 29746501

Mouse hypothalamus — 72 h fasting (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Fasted 72h vs Fed

Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus.

PMID 40743333

Mouse arcuate AGRP neurons — fed vs fasting (RNA-seq)

Mus musculus · RNA-seq (sorted AGRP neurons) · Arcuate nucleus

Fasted vs Fed

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss.

PMID 26329458

Mouse arcuate POMC neurons — Drd2+ vs broad (RiboTag)

Mus musculus · RiboTag (translatome) · Arcuate nucleus

Drd2+ POMC vs Broad POMC

Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature.

PMID 36345942

Mouse hypothalamus — hibernation cis-element KO (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

CNE KO vs WT

Conserved noncoding cis elements associated with hibernation modulate metabolic and behavioral adaptations in mice.

PMID 40743330

Mouse arcuate POMC neurons — fed vs fasting (RNA-seq)

Mus musculus · RNA-seq (sorted POMC neurons) · Arcuate nucleus

Fasted vs Fed

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss.

PMID 26329458

Mouse arcuate AGRP neurons — fed vs fasting (NuTRAP)

Mus musculus · TRAP-seq (NuTRAP translatome) · Arcuate nucleus

Fasted vs Fed

AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin's acute effects.

PMID 38821928

Mouse hypothalamus — 16 h fasting (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Fasted 16 h vs Ad libitum fed

Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice.

PMID 41129636

Mouse hypothalamus — 18 h fasting (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Fasted 18 h vs Fed

Whole Transcriptome Analysis of Hypothalamus in Mice during Short-Term Starvation.

PMID 36834616

Aged mouse hypothalamus — acute dietary restriction (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Acute dietary restriction vs Ad libitum

Atlas of the aging mouse brain reveals white matter as vulnerable foci.

PMID 37591239

Aged mouse hypothalamus — caloric restriction (spatial RNA-seq)

Mus musculus · spatial RNA-seq · Whole hypothalamus

Caloric restriction vs Ad libitum

Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain.

PMID 40833855

Mouse whole hypothalamus — 24-hour food deprivation (scRNA-seq)

Mus musculus · scRNA-seq · Whole hypothalamus

Food deprived (24 h) vs Normal fed

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity.

PMID 28355573

Mouse AgRP neurons — 24-hour fasting at ZT14 (RiboTag RNA-seq)

Mus musculus · RiboTag translatome · Arcuate nucleus

Fasted (24 h) vs Ad libitum fed

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron.

PMID 30827863

Mouse arcuate nucleus — 24-hour food deprivation (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Arcuate nucleus

Food deprived (24 h) vs Ad libitum fed

Laser-capture-microdissected arcuate nucleus from male C57BL/6 mice, ad-libitum fed vs 24-hour food deprived, n=5/5 independent animals. Other hypothalamic nuclei in the series are excluded (GSE96627)

Mouse SCN — time-restricted Western-diet feeding

Mus musculus · bulk RNA-seq · Suprachiasmatic nucleus

Nine-hour time-restricted Western diet vs Western diet ad libitum

Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals.

PMID 36599299

Chicken hypothalamus — L-citrulline diet

Gallus gallus · bulk RNA-seq · Whole hypothalamus

1% L-citrulline at 24 °C vs Basal diet at 24 °C

Transcriptomics analysis unveils key potential genes associated with brain development and feeding behavior in the hypothalamus of L-citrulline-fed broiler chickens.

PMID 37844531

Chicken hypothalamus — residual feed intake

Gallus gallus · bulk RNA-seq · Whole hypothalamus

High residual feed intake vs Low residual feed intake

Hypothalamus RNA-seq comparing five high-residual-feed-intake with five low-residual-feed-intake male Korat-chicken RNA pools, each pool representing two birds. Pituitary libraries are excluded; integer counts are conservatively mapped to current chicken symbols without orthology inference (GSE278826)

Piglet hypothalamus — formula composition

Sus scrofa · bulk RNA-seq · Whole hypothalamus

Alpha-lactalbumin-enriched formula vs Whey-protein-isolate formula

Functional gut variability drives metabolic and transcriptional features in neonatal piglets.

PMID 41102179

Cattle hypothalamus — early-life plane of nutrition

Bos taurus · bulk RNA-seq · Whole hypothalamus

High plane of nutrition vs Moderate plane of nutrition

A high plane of nutrition during early life alters the hypothalamic transcriptome of heifer calves.

PMID 34234169

Cattle arcuate nucleus — early-life plane of nutrition

Bos taurus · bulk RNA-seq · Arcuate nucleus

High plane of nutrition vs Moderate plane of nutrition

A high plane of nutrition during early life alters the hypothalamic transcriptome of heifer calves.

PMID 34234169

Pig hypothalamus — post-weaning low-growth syndrome

Sus scrofa · bulk RNA-seq · Whole hypothalamus

Low growth vs High growth

Day-39 hypothalamus RNA-seq comparing six low-growth with six high-growth weanling pigs. Ileum and day-7 libraries are excluded; official Kallisto-derived fractional gene-level count estimates are retained without rounding and modeled by edgeR-QL (GSE324226)

Cattle hypothalamus — short-term diet restriction

Bos taurus · bulk RNA-seq · Whole hypothalamus

Restricted-diet anovulatory vs Higher-feed ovulatory control

Effect of short term diet restriction on gene expression in the bovine hypothalamus using next generation RNA sequencing technology.

PMID 29121875

Mouse POMC response to food cues

Mus musculus · bulk RNA-seq · Arcuate nucleus

Food cues vs nonedible object

Six POMC-RiboTag mice per condition after a 16-hour fast. Only the 5,764 genes in the deposited CPM matrix are available; results and pathway coverage are restricted to that gene universe. The matrix is summed on the linear scale for duplicate symbols and transformed as log2(CPM+1) for limma. Counts are not reconstructed from CPM. Cage identifiers are not deposited.

Mouse hypothalamus — ob/ob vs WT (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

ob/ob vs WT

ob/ob (leptin-deficient) vs wild-type hypothalamus transcriptome (GSE167264)

Mouse arcuate PNOC neurons — LepR WT vs KO (bacTRAP)

Mus musculus · bacTRAP (translatome) · Arcuate nucleus

LepR KO vs LepR WT

Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis.

PMID 40273910

Mouse hypothalamic LepRb neurons — Stat3 KO (TRAP-seq)

Mus musculus · TRAP-seq (translatome) · Whole hypothalamus

Stat3 KO vs Control

Transcriptional and physiological roles for STAT proteins in leptin action.

PMID 30718218

Mouse mediobasal tanycytes — chow vs HFD (BAC-TRAP)

Mus musculus · TRAP-seq (translatome) · Whole hypothalamus

HFD vs NCD

Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity.

PMID 34931084

Mouse hypothalamus — peripheral insulin (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Insulin vs Saline

Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens.

PMID 34031123

Mouse arcuate nucleus — Kcnb1 KO (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Arcuate nucleus

Kcnb1 KO vs WT

KCNB1-Leptin receptor complexes couple electric and endocrine function in the melanocortin neurons of the hypothalamus.

PMID 39436109

Mouse hypothalamus (ob/ob) — central FGF1 (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

FGF1 vs Vehicle

Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission.

PMID 32895383

Mouse hypothalamus — neonatal STZ diabetes (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Diabetic vs Control

Hypothalamus, control vs neonatal-STZ diabetes — diabetic hypothalamic transcriptome (GSE329555)

Mouse hypothalamus — high vs low glycaemia in TallyHo mice (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

High blood glucose vs Low blood glucose

Early body weight gain in TALLYHO/JngJ mice predicts adult diabetic phenotype, mimicking childhood obesity

Rat hypothalamus — endurance training (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

Endurance training (8 weeks) vs Sedentary (8 weeks)

Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures.

PMID 38697122

Mouse hypothalamus — Clic1 knockout (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Clic1 knockout vs Wild type

Targeting Clic1 for the treatment of obesity: A novel therapeutic strategy to reduce food intake and body weight.

PMID 37604246

Mouse hypothalamus — neuronal Smc3 knockout (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Neuronal Smc3 cKO vs Cre-negative control

Male Smc3-floxed mouse whole hypothalamus five weeks after tamoxifen, seven Cre-negative controls vs five Camk2a-CreERT2-positive neuronal Smc3 conditional-knockout animals. Setmelanotide was not a sequenced arm (GSE243287)

Mouse hypothalamus — choroid-plexus Ins2 overexpression (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Choroid-plexus Ins2 overexpression vs Untreated control

AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences.

PMID 37515772

Mouse medial preoptic PNOC neurons — BacTRAP enrichment

Mus musculus · BacTRAP translatome · Preoptic area

PNOC-neuron ribosome IP vs Matched total input

Medial-preoptic-area BacTRAP from 17-18-week-old female NuTRAP::Pnoc-Cre mice: three independent pools of three animals, with matched total input and PNOC-neuron ribosome-IP libraries modeled as pairs. This is IP enrichment, not a treatment response (GSE306829)

Mouse VMH — thyroid-hormone-receptor beta knockout

Mus musculus · bulk RNA-seq · Ventromedial hypothalamus

AAV-Cre Thrb knockout vs AAV-GFP control

Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight.

PMID 28614708

Mouse GT1-7 hypothalamic neurons — orexin-A response

Mus musculus · bulk RNA-seq · Whole hypothalamus

Orexin-A, 3 hours vs Vehicle, 3 hours

Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line.

PMID 29145494

Mouse hypothalamus — THRB K146Q mutation

Mus musculus · bulk RNA-seq · Whole hypothalamus

THRB K146Q mutant vs Wild type

Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production.

PMID 34237030

Mouse hypothalamus — GLP-1/GIP dual agonist (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

GLP-1/GIP dual agonist vs Vehicle

GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.

PMID 42056522

Mouse arcuate nucleus — PYY/GLP-1 co-agonist (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Arcuate nucleus

PYY/GLP-1 co-agonist vs Vehicle

Peptide-YY(3-36)/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.

PMID 34781035

Mouse hypothalamus — aged ± GLP-1R agonist (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Aged + GLP-1RA vs Aged control

Body-wide multi-omic counteraction of aging with GLP-1R agonism.

PMID 41265449

Mouse hypothalamus — risperidone (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Risperidone vs Control

The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain.

PMID 33978701

Mouse hypothalamus — Gly-Low compound (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Gly-Low vs Control diet

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

PMID 41086114

Mouse hypothalamic oxytocin neurons — CCK-8s (RiboTag)

Mus musculus · RiboTag translatome · Whole hypothalamus

CCK-8s vs Vehicle

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.

PMID 37864798

Mouse hypothalamus — GLP-1 mono-agonist (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

GLP-1 vs Vehicle

GLP-1-directed NMDA receptor antagonism for obesity treatment.

PMID 38750368

Mouse hypothalamus — celastrol in DIO (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Celastrol vs Vehicle

Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.

PMID 38569472

Mouse hypothalamic neurons — cannabidiol exposure (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

CBD 3 µM (24 h) vs Vehicle (24 h)

Elucidating the transcriptomic response of adult-derived mHypoA-2/12 mouse hypothalamic neuron cell line to cannabidiol (CBD) exposure.

PMID 40335839

Mouse hypothalamic neurons — mogroside V exposure (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Mogroside V 160 µM vs Normal glucose vehicle

Cultured adult mouse hypothalamic neuronal cells under normal glucose, vehicle vs 160 µM mogroside V, three RNA profiles per arm; independent culture preparations have not been established. Lower doses and high-glucose arms are excluded from this focused contrast (GSE275887)

Mouse arcuate nucleus — cagrilintide response (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Arcuate nucleus

AM833 / cagrilintide vs Vehicle

Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3.

PMID 40609154

Mouse hypothalamus — GLP-1/dexamethasone conjugate (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

GLP-1/dexamethasone vs Vehicle

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

PMID 28943448

Mouse hypothalamus TN-783 in diet-induced obesity

Mus musculus · bulk RNA-seq · Whole hypothalamus

TN-783 vs vehicle in DIO; DIO vehicle vs lean untreated

Six mice each in lean untreated, diet-induced obese vehicle and DIO TN-783 groups. Limma uses the author-supplied log2 CPM sheet without a second logarithm or count model. Duplicate gene-symbol rows are averaged on the supplied log scale. Salmon estimates are retained in the workbook but are not treated as integer raw counts.

Mouse hypothalamus — Akkermansia intervention (scRNA-seq)

Mus musculus · scRNA-seq · Whole hypothalamus

Fructose + A. muciniphila vs Fructose control

Cross-tissue multiomics reveals that Akkermansia muciniphila counteracts metabolic syndrome by reprograming gut microbiota, oleoylethanolamide and the gut-hypothalamus axis

Mouse mediobasal hypothalamus — maternal emulsifier exposure

Mus musculus · bulk RNA-seq · Whole hypothalamus

Maternal emulsifiers (1% CMC + 1% P80) vs Maternal control

Maternal emulsifier consumption programs offspring metabolic and neuropsychological health in mice.

PMID 37616199

Mouse hypothalamus chronic colitis and intestinal Opa1 deletion

Mus musculus · bulk RNA-seq · Whole hypothalamus

DSS colitis vs control; Intestinal Opa1 deletion vs floxed control

Only hypothalamus is included. Multiple organs from the same mouse are not extra replicates. D09Hy and Op57Hy are absent from processed counts. WT/DSS and Opa1/flox cohorts are analyzed separately.

Mouse hypothalamus acute colitis

Mus musculus · bulk RNA-seq · Whole hypothalamus

DSS colitis vs control

Only hypothalamus is included. Multiple organs from the same mouse are not extra replicates.

Mouse preoptic area — pooled dnFGFR genotype effect (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Preoptic area

dnFGFR vs Control

Opposite sex housing enhances reproductive function and induces transcriptional changes in the preoptic area of GnRH-deficient mice.

PMID 40303641

Mouse hypothalamus — POMC membrane-estrogen KO (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

POMC-C451A KO vs WT

Membrane-initiated estrogen receptor-α signaling in the hypothalamus regulates trabecular bone in femur in female mice.

PMID 42133461

Mouse hypothalamus — maternal vs artificial rearing (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Artificially reared vs Maternally reared

Early-life maternal care is required for the typical development of calming responses to back stroking.

PMID 41963499

Mouse GnRH/POA — prenatal androgenization (TRAP-seq)

Mus musculus · TRAP-seq (translatome) · Preoptic area

Prenatal DHT vs Vehicle

Prenatal Androgenization Alters the Development of GnRH Neuron and Preoptic Area RNA Transcripts in Female Mice.

PMID 33095238

Mouse VMHvl — estradiol vs vehicle (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Ventromedial hypothalamus

Estradiol benzoate vs Vehicle

Oestrogen engages brain MC4R signalling to drive physical activity in female mice.

PMID 34646010

Developing mouse VMH Sf1 neurons — female vs male (scRNA-seq)

Mus musculus · scRNA-seq · Ventromedial hypothalamus

Male (P10) vs Female (P10)

Hypothalamic estrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure.

PMID 32377634

Mouse postnatal arcuate nucleus — Mettl14 KO (scRNA-seq)

Mus musculus · scRNA-seq · Arcuate nucleus

Mettl14 KO vs Control

m(6)A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice.

PMID 40112816

Rat mediobasal hypothalamus / preoptic area — perinatal EDC mixture (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

EDC mixture (F1) vs Vehicle (F1)

Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat.

PMID 34383603

Rat mediobasal hypothalamus — perinatal DES exposure (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

Perinatal DES 12 µg/kg/day (P90) vs Vehicle (P90)

Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats.

PMID 37077353

Mouse GT1-7 hypothalamic neurons — MKRN3 overexpression (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

MKRN3 overexpression vs Wild type

MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty.

PMID 33744966

Mouse GT1-7 hypothalamic neurons — Alisol B treatment (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Alisol B 0.125 uM (24 h) vs Vehicle control (24 h)

GT1-7 mouse hypothalamic GnRH-neuron cultures, matched control vs 0.125 uM Alisol B for 24 hours, three RNA profiles per arm. Independent culture preparations or experiment batches are not documented. This is an in-vitro model (GSE253875)

Rat mediobasal hypothalamus — EED overexpression (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

EED-overexpressing lentivirus vs GFP lentiviral control

Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression.

PMID 33479437

Mouse P22 hypothalamus — Lef1 conditional knockout

Mus musculus · bulk RNA-seq · Whole hypothalamus

P22 Lef1 conditional knockout vs P22 Lef1 control

Lef1-dependent hypothalamic neurogenesis inhibits anxiety.

PMID 28837622

Human hypothalamic neural stem cells — hPSC differentiation

Homo sapiens · bulk RNA-seq · Whole hypothalamus

Hypothalamic neural stem cells vs Human pluripotent stem cells

Bulk RNA-seq comparing three human pluripotent-stem-cell cultures with three independently prepared hypothalamus-specific neural-stem-cell cultures. The official StringTie gene-count columns are modeled as a focused in-vitro differentiation contrast (GSE214877)

Mouse hypothalamus — estrus versus diestrus

Mus musculus · bulk RNA-seq · Whole hypothalamus

Diestrus vs Estrus

A multi-tissue transcriptomic landscape of female mice in estrus and diestrus provides clues for precision medicine.

PMID 36589755

Mouse hypothalamus — female pubertal transition

Mus musculus · bulk RNA-seq · Whole hypothalamus

Female PND37 vs Female PND22

Related methods publication: Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland.

PMID 36221127

Mouse arcuate neurons — postnatal development

Mus musculus · bulk RNA-seq · Arcuate nucleus

Female NeuN-positive PND35 vs Female NeuN-positive PND12

Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index.

PMID 36170368

Chicken hypothalamus — juvenile growth

Gallus gallus · bulk RNA-seq · Whole hypothalamus

6-week broilers vs 3-week broilers

Transcriptomic Changes in Broiler Chicken Hypothalamus during Growth and Development.

PMID 30406127

Zebrafish hypothalamus — fluoxetine lineage

Danio rerio · bulk RNA-seq · Whole hypothalamus

Fluoxetine-exposed lineage vs Vehicle-control lineage

Unstressed adult hypothalamus RNA-seq comparing six independent pools from a fluoxetine-exposed lineage with six vehicle-lineage pools. Acute-stress, telencephalon, and larval-head samples are excluded; official STAR raw counts and the exact GRCz11 release-92 annotation are used (GSE141144)

Pig hypothalamus — Iberian genotype

Sus scrofa · bulk RNA-seq · Whole hypothalamus

Pure Iberian vs Iberian × Large White

Whole-hypothalamus RNA-seq comparing ten pure Iberian with ten Iberian × Large White pigs at two months, balanced five female and five male per genotype and adjusted for sex. GEO-described normalized expression is transformed as log2(x+1); five HTSeq summary rows are quarantined and no integer-looking values are reinterpreted as raw counts (GSE201408)

Human hypothalamic neurons — MKRN3 deficiency

Homo sapiens · bulk RNA-seq · Whole hypothalamus

MKRN3 deficient vs MKRN3 wild type

MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.

PMID 37092553

Mouse postnatal hypothalamus — microglia depletion

Mus musculus · bulk RNA-seq · Whole hypothalamus

PLX3397 P9-P15 vs Vehicle P9-P15

Microglia shape AgRP neuron postnatal development via regulating perineuronal net plasticity.

PMID 38001338

Zebrafish hypothalamus — cyp19a1b mutation

Danio rerio · bulk RNA-seq · Whole hypothalamus

cyp19a1b mutant vs Wild type

Mutation of Brain Aromatase Impairs Behavior and Neuroplasticity in Adult Zebrafish.

PMID 40853063

Mouse tuberal-hypothalamic SST neurons — sex comparison

Mus musculus · bulk RNA-seq · Whole hypothalamus

Male vs Female

Feeding neurons integrate metabolic and reproductive states in mice.

PMID 37817932

Human hypothalamus-pituitary organoids — differentiation outcome

Homo sapiens · bulk RNA-seq · Whole hypothalamus

Predicted differentiation success vs Predicted differentiation failure

Prediction of the hypothalamus-pituitary organoid formation using machine learning.

PMID 40763741

African striped mouse medial preoptic parental behavior

Rhabdomys pumilio · snRNA-seq · Preoptic area

Alloparental vs naive control males; Infanticidal vs naive control males; Sires vs naive control males; Dams vs sires

African striped mouse medial preoptic snRNA-seq: three naive control, three alloparental and three infanticidal males, four sires and four dams. One animal per source object. The source study aligned reads to the Rhabdomys pumilio genome; the retained processing used mouse annotation and pathway references, whose cross-species mapping requires review. Dam-versus-sire differences combine sex and parental-role differences, and the dams and sires are mating pairs whose pairing is absent from the current model (Nature 2026, PMID 41708861; GSE314184).

PMID 41708861

Mouse preoptic sex differences

Mus musculus · scRNA-seq · Preoptic area

Male vs female pools

Three independent female pools and three independent male pools, each containing three mice. GEO explicitly maps matrix barcode suffixes 1-6 to the six pools. Cells are summed within each pool; the 18 mice do not provide 18 independent transcriptomic replicates. This track aggregates all submitted preoptic cell types.

PMID 30385464

Mouse hypothalamus Gough Island divergence

Mus musculus · bulk RNA-seq · Whole hypothalamus

Gough Island vs WSB, adjusted for sex

Ten four-week-old Gough Island and ten WSB hypothalamus samples, each strain with five females and five males. RSEM expected counts, TPM and effective lengths supply a lengthScaledTPM import that preserves library totals. The model adjusts for sex. Litter identity is unavailable in the deposited sample metadata, so litter effects cannot be separated.

Mouse hypothalamus — maternal obesity (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Maternal HFHS vs Maternal low-fat

Maternal obesity interrupts the coordination of the unfolded protein response and heat shock response in the postnatal developing hypothalamus of male offspring in mice.

PMID 33636254

Mouse arcuate POMC neurons — maternal HFD (RiboTag)

Mus musculus · RiboTag (translatome) · Arcuate nucleus

Maternal HFD vs chow · at P0; Maternal HFD vs chow · at P21; P21 vs P0 · chow arm (maturation); P21 vs P0 · HFD arm (maturation)

Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice.

PMID 32283518

Mouse hypothalamus — maternal Western diet (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Maternal Western diet vs Maternal regular diet

Maternal Western diet programs cardiometabolic dysfunction and hypothalamic inflammation via epigenetic mechanisms predominantly in the male offspring.

PMID 38159883

Rat neonatal hypothalamus maternal HFD

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

Maternal HFD vs control

Maternal 43% versus 12% fat-derived energy exposure through gestation and lactation; offspring sampled at postnatal day 10. Six samples per diet are analyzed separately within each sex. The paper defines n as litters, but GEO omits sample-to-litter identifiers. Deposited workbooks include authentic per-sample raw counts; the analysis universe is restricted to their submitted rows. Excel-damaged symbols remain unassigned feature IDs.

PMID 29240779

Mouse hypothalamus — 22 months vs 12 weeks (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Aged (22 months) vs Young (12 weeks)

Transcriptomic analysis to identify genes associated with hypothalamus vulnerability in aging mice with cognitive decline.

PMID 38452974

Mouse hypothalamus — 27 vs 6 months (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Aged (27 months) vs Young (6 months)

Multitissue, multi-time point transcriptomic atlas of aging in mice and rats.

PMID 41984968

Mouse hypothalamus — circadian-adjusted aging (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Aged (27 months) vs Young (6 months)

Defining the age-dependent and tissue-specific circadian transcriptome in male mice.

PMID 36640301

Mouse hypothalamus — 21 vs 3 months (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Aged (21 months) vs Young (3 months)

Atlas of the aging mouse brain reveals white matter as vulnerable foci.

PMID 37591239

Mouse hypothalamic astrocytes — 2 years vs 4 months (RiboTag RNA-seq)

Mus musculus · RiboTag translatome · Whole hypothalamus

Aged (2 years) vs Young (4 months)

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain.

PMID 29298427

Mouse hypothalamus — 23 vs 4 months (spatial RNA-seq)

Mus musculus · spatial RNA-seq · Whole hypothalamus

Aged (23 months) vs Young (4 months)

Optics-free spatial genomics for mapping mammalian brain aging by IRISeq.

PMID 42120609

Rhesus macaque hypothalamus — middle age (bulk RNA-seq)

Macaca mulatta · bulk RNA-seq · Whole hypothalamus

Middle-aged (9.8-10 years) vs Young (3.2-5 years)

Transcriptomic and open chromatin atlas of high-resolution anatomical regions in the rhesus macaque brain.

PMID 31980617

Rat hypothalamus — 27 months vs 6 months (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

Aged (27 months) vs Young (6 months)

Multitissue, multi-time point transcriptomic atlas of aging in mice and rats.

PMID 41984968

Rat supraoptic nucleus — age-dependent transcriptome

Rattus norvegicus · bulk RNA-seq · Supraoptic nucleus

125 days old vs 35 days old

Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity.

PMID 37711995

Mouse arcuate nucleus — REV-ERBα/β DKO (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Arcuate nucleus

REV-ERB DKO vs Control

Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice.

PMID 33021965

Mouse SCN — control vs MCD diet (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Suprachiasmatic nucleus

MCD diet vs Control

Suprachiasmatic nucleus, control vs methionine/choline-deficient diet (GSE252364)

Mouse SCN — chow vs high-fat diet (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Suprachiasmatic nucleus

High-fat diet vs Chow

Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge.

PMID 33172990

Mouse arcuate nucleus — hepatic clock DKO (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Arcuate nucleus

Hep-clock DKO vs Control

Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake.

PMID 39509517

Mouse VLPO galanin neurons — sleep deprivation

Mus musculus · bulk RNA-seq · Preoptic area

Sleep deprivation at ZT6 vs Spontaneous sleep at ZT6

RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake.

PMID 32928100

Mouse hypothalamus — circadian-rhythm disruption

Mus musculus · bulk RNA-seq · Whole hypothalamus

8-week circadian-rhythm disruption vs 8-week control

Whole-hypothalamus RNA-seq from five 8-week control and five 8-week circadian-rhythm-disrupted mice. Aged animals and non-hypothalamic tissues are excluded; the official FPKM values are analyzed as documented log2(FPKM+1) without rounding (GSE264350)

Siberian-hamster tanycytes — early photoperiod history

Phodopus sungorus · bulk RNA-seq · Whole hypothalamus

Short-to-intermediate photoperiod vs Long-to-intermediate photoperiod

Laser-captured P50 tanycyte-zone RNA-seq comparing five hamsters gestated and reared under short versus five under long photoperiod before both moved to intermediate photoperiod. Constant-photoperiod arms are excluded; deposited featureCounts use the authors' explicit Liftoff projection to mouse GRCm39 IDs (GSE204883)

Djungarian-hamster hypothalamus — spontaneous daily torpor

Phodopus sungorus · bulk RNA-seq · Whole hypothalamus

Short-photoperiod spontaneous torpor vs Short-photoperiod normothermia

Comparative transcriptomics of the Djungarian hamster hypothalamus during short photoperiod acclimation and spontaneous torpor.

PMID 34894101

Siberian-hamster MBH — short photoperiod

Phodopus sungorus · bulk long-read RNA-seq · Whole hypothalamus

Four weeks short day vs Long day

Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals.

PMID 41527434

Garden-dormouse hypothalamus — early torpor

Eliomys quercinus · bulk RNA-seq · Whole hypothalamus

Early torpor vs Interbout arousal

Comparative transcriptomics of the garden dormouse hypothalamus during hibernation.

PMID 37925593

Mouse SCN — scheduled voluntary exercise

Mus musculus · bulk RNA-seq · Suprachiasmatic nucleus

Wild-type scheduled voluntary exercise vs Wild-type without scheduled exercise

Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain's suprachiasmatic clock.

PMID 36866044

Mouse SCN — developmental photoperiod

Mus musculus · bulk RNA-seq · Suprachiasmatic nucleus

Long photoperiod vs Short photoperiod

Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice.

PMID 39096022

Mouse PVN sleep-rebound ensembles

Mus musculus · bulk RNA-seq · Paraventricular nucleus

Rebound vs control sleep

Five control and four rebound pools, each containing seven mice. Only immunoprecipitated RNA is compared. Input assays are paired to these pools and excluded from this track.

Mouse SCN NPAS4 and light response

Mus musculus · bulk RNA-seq · Suprachiasmatic nucleus

Knockout vs wild type in dark; Knockout vs wild type after light; Light vs dark in wild type; Light vs dark in knockout

NPAS4 bulk experiment only. Each genotype/light arm has three independent pools of six SCN pairs. Time-course and ChIP assays are separate experiments and excluded.

PMID 34416169

Mouse preoptic response to isoflurane

Mus musculus · snRNA-seq · Preoptic area

Isoflurane vs oxygen, adjusted for sex

Twenty independently sequenced mice, five of each sex per oxygen/isoflurane arm. Submitted excitatory, inhibitory and non-neuronal nuclei are summed within each mouse. Treatment models adjust for sex. GSE243489 supplies the reference taxonomy and contributes no samples.

BL/6 mouse hypothalamic Treg pools — standard diet vs HFD (bulk RNA-seq)

Mus musculus · bulk RNA-seq (sorted Tregs) · Whole hypothalamus

HFD vs Std diet

Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments.

PMID 40113758

Mouse hypothalamus — normoxia vs hypoxia (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Hypoxia vs Normoxia

Reprogramming of glucocorticoid receptor function by hypoxia.

PMID 34699114

Mouse paraventricular nucleus — dexamethasone (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Paraventricular nucleus

Dexamethasone vs Control

DiffBrainNet: Differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions.

PMID 36532379

Mouse hypothalamus — oxaliplatin cachexia (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Oxaliplatin vs Control

Oxaliplatin triggers adipose and muscle wasting through cancer-independent metabolic and CNS pathways in mouse models.

PMID 42270763

Mouse hypothalamus — Abi3 KO (bulk RNA-seq)

Mus musculus · bulk RNA-seq (QuantSeq) · Whole hypothalamus

Abi3 KO vs WT

Deletion of the Alzheimer's disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice.

PMID 36620768

Mouse hypothalamus — Ube3a duplication (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Ube3a 2x vs WT

Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral, and transcriptomic levels.

PMID 38996019

Mouse hypothalamus — muscle COX10 KO (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

COX10 KO vs Control

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.

PMID 37222423

Mouse hypothalamus — pituitary stalk lesion (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Stalk lesion (10 d) vs Sham

Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ deposition.

PMID 38796566

Mouse PVN CRH neurons — early-life adversity (scRNA-seq)

Mus musculus · scRNA-seq · Paraventricular nucleus

Early-life adversity vs Control rearing

Single-Cell Transcriptional Changes in Hypothalamic Corticotropin-Releasing Factor-Expressing Neurons After Early-Life Adversity Inform Enduring Alterations in Vulnerabilities to Stress.

PMID 36712559

Mouse hypothalamus — prenatal benzene exposure (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

Prenatal benzene vs Filtered air

Prenatal benzene exposure in mice alters offspring hypothalamic development predisposing to metabolic disease in later life.

PMID 37084897

Rat supraoptic nucleus — 72-hour water deprivation (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Supraoptic nucleus

Water deprived (72 h) vs Euhydrated

Osmoregulation of the transcriptome of the hypothalamic supraoptic nucleus: A resource for the community.

PMID 34297454

Rat paraventricular nucleus — sodium depletion (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Paraventricular nucleus

Sodium depleted (24 h) vs Control

Physiological and Transcriptomic Changes in the Hypothalamic-Neurohypophysial System after 24 h of Furosemide-Induced Sodium Depletion.

PMID 31955161

Rat paraventricular nucleus — adolescent restraint stress (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Paraventricular nucleus

Adolescent restraint stress vs Nonstress

Subregion-specific transcriptomic profiling of rat brain reveals sex-distinct gene expression impacted by adolescent stress.

PMID 38977070

Rat medial preoptic area — early-life adversity (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Preoptic area

Limited bedding/nesting (P2-P9) vs Standard housing

Effects of early life adversity on male reproductive behavior and the medial preoptic area transcriptome

Rat hypothalamus — acute ozone exposure (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

Ozone 0.8 ppm (4 h) vs Filtered air (4 h)

Ozone-Induced Dysregulation of Neuroendocrine Axes Requires Adrenal-Derived Stress Hormones.

PMID 31397875

Mouse hypothalamus — systemic LPS challenge (bulk RNA-seq)

Mus musculus · bulk RNA-seq · Whole hypothalamus

LPS + vehicle vs Saline + vehicle

Orexin Receptor Antagonism Improves Sleep Quality and Mitigates Lipopolysaccharide-Induced Inflammatory Responses in a Mouse Model.

PMID 41511173

Rat PVN — immobilization stress (bulk RNA-seq)

Rattus norvegicus · bulk RNA-seq · Paraventricular nucleus

Immobilization stress vs Untreated control

The effects of hypothalamic microglial activation on ventricular arrhythmias in stress cardiomyopathy.

PMID 39935443

Human iPSC-derived hypothalamic neurons — inherited obesity

Homo sapiens · bulk RNA-seq · Whole hypothalamus

Constitutionally obese donors vs Healthy control donors

Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses.

PMID 29681516

Rat rostral posterior hypothalamus — repeated noise stress

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

Seven daily noise-stress exposures vs No-stress control

Determination of steady-state transcriptome modifications associated with repeated homotypic stress in the rat rostral posterior hypothalamic region.

PMID 37360161

Chicken POAH — embryonic heat conditioning

Gallus gallus · bulk RNA-seq · Preoptic area

Embryonic heat conditioning vs Conventional incubation

Embryonic thermal conditioning and post-hatch heat challenge alter hypothalamic expression of genes related to appetite, thermoregulation, and stress modulation in broiler chicks.

PMID 40600125

Mouse arcuate nucleus — chronic corticosterone

Mus musculus · bulk RNA-seq · Arcuate nucleus

Four-week corticosterone vs Four-week vehicle

Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment.

PMID 31176677

Rat fetal hypothalamus — maternal ozone exposure

Rattus norvegicus · bulk RNA-seq · Whole hypothalamus

Maternal 0.8-ppm ozone vs Maternal filtered air

Ozone-induced fetal growth restriction in rats is associated with sexually dimorphic placental and fetal metabolic adaptation.

PMID 33031959

Piglet hypothalamus — maternal immune activation

Sus scrofa · bulk RNA-seq · Whole hypothalamus

Nursed MIA-exposed offspring vs Nursed control offspring

Epigenetic disruptions in the offspring hypothalamus in response to maternal infection.

PMID 38431234

Mouse hypothalamus — lactational heat stress

Mus musculus · bulk RNA-seq · Whole hypothalamus

Heat stress, 36 °C vs Control, 25 °C

Transcriptional changes in the hypothalamus, pituitary, and mammary gland underlying decreased lactation performance in mice under heat stress.

PMID 31480864

Pig hypothalamus — maternal PRRSV exposure

Sus scrofa · bulk RNA-seq · Whole hypothalamus

Maternal PRRSV, offspring saline vs Maternal control, offspring saline

Immune and metabolic challenges induce changes in pain sensation and related pathways in the hypothalamus.

PMID 38189117

Mouse hypothalamus SRC-1 deletion

Mus musculus · bulk RNA-seq · Whole hypothalamus

SRC-1 knockout vs wild type

Three wild-type and three SRC-1 knockout hypothalamus samples. GEO sample descriptions explicitly map YX3878-YX3883 to the featureCounts columns.

PMID 40882002

Rat PVN hypertension

Rattus norvegicus · bulk RNA-seq · Paraventricular nucleus

SHR vs Wistar, adjusted for sex

Nine Wistar and ten spontaneously hypertensive rats. Sex is a model covariate; the deposited cohort lacks Wistar male 1.

PMID 41723507

Mouse hypothalamus cancer cachexia

Mus musculus · bulk RNA-seq · Whole hypothalamus

CT-26 cachexia vs healthy control

Three CT-26 cachexia and three healthy mice. Only hypothalamus samples are included. Deposited RSEM gene TPM, effective lengths and expected counts are imported with lengthScaledTPM correction; fractional estimates are retained. Each corrected library preserves its original expected-count total.